Gonadotropin-Releasing Hormone Agonist Combined with Hormone Replacement Therapy Protocol Improves the Live Birth Rate in Frozen-Thawed Embryo Transfer Cycles for Patients without Endometriosis

Background: Whether gonadotropin-releasing hormone agonist (GnRH-a) pituitary suppression improves clinical outcomes in non-endometriosis patients undergoing frozen embryo transfer remains controversial. The objective of this study is to investigate whether GnRHa combined with replacement treatment (HRT) compared HRT alone can improve the frozen-thawed without endometriosis. Methods: This a retrospective cohort study. involved 2178 (FET) cycles between January 2018 and December 2019, these cycles, 1535 were GnRHa-HRT 643 cycles. primary pregnancy live birth rates. SPSS software (version 23.0, IBM Corp., Chicago, IL, USA) was used for data analysis. Results: Single-factor analysis showed that implantation rates -were higher group than those (p < 0.05). mid-to-late-term miscarriage rate lower human chorionic gonadotropin (HCG) positivity, pregnancy, early abortion, multiple preterm delivery two groups comparable. Multivariate logistic regression = 0.009), there no significant difference 0.103). Conclusions: large-scale revealed women FET may benefit from downregulation due increasing rate.